Inhaled Solvent Addiction leads to poor decision-making and social isolation, new study says
Neuroscientist Dr. Rohani Cena-Navarro (left) and research associate Johanna Muna (right) of the University of the Philippines National Institutes of Health (UP-NIH), investigate the effects of solvent exposure on an experimental rat. The team of experts have identified new long-term behavioral and brain problems caused by inhaled solvents that they are hoping to reverse with future treatments.
A team of Filipino scientists and experts have found previously unreported effects of solvent abuse on social behavior and decision-making in a rat model. These findings are expected to pave the way for future treatments of adolescents struggling with inhaled solvent addiction.
The study, “Novel Approaches to Treatment of Addiction and Depression using Animal Models,” suggests that the brain’s ability to process information is heavily affected by repeated inhaled solvent use. Over time, it becomes difficult for individuals to make wise choices and engage in normal social interactions. This can lead to societal withdrawal and a deepened cycle of addiction.
Unlike prior studies, both male and female rats were studied, reflecting the use of abused inhalants by boys and girls. “This will allow us to develop treatments that are equally effective in both sexes,” program leader Dr. Rohani Cena-Navarro said.
The research was published in the international journal, Psychopharmacology, on Dec. 18, 2024, and was funded by the Department of Science and Technology. It was carried out by the UP Manila National Institutes of Health, together with experts from the National Center for Mental Health, the UP College of Medicine, the UP Philippine General Hospital, and the UP Diliman College of Science Institute of Chemistry.#
Text by Jennifer F. ManongdoPhoto by Dr. Rohani Cena-Navarro