The University of the Philippines Manila Development Foundation, Inc. (UPMDFI) is duly registered with the Securities and Exchange Commission (SEC) as a non-stock and non-profit corporation to encourage, support, assist, and finance projects and programs dedicated to the pursuit of specific purposes for which the Foundation is formed.

It was registered in 1987, however it started functioning only in 1995.

The Foundation aims to contribute to the development and growth of UP Manila and the national welfare through the establishment and operation of a private institutional medium to encourage, undertake, and/or underwrite the following programs:

Institutional Development Programs

Basic and Applied Research

Creative Work in the Health Sciences, Physical, Biology, Social Development Studies, and the Humanities

The Foundation shall endeavour to supplement the resources made available by the government and income generated by the University to promote the ever growing needs of the campus in terms of: Human Resource Development; Research, Publication and Creative Work; Institutional Development and Advocacy and Social Transformation for National Development.